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Target
Polymerase acidic protein
Ligand
BDBM474356
Substrate
n/a
Meas. Tech.
Endonuclease Inhibition Assay
IC50
40.0±n/a nM
Citation
 Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent  US11453677 Publication Date 9/27/2022 
Target
Name:
Polymerase acidic protein
Synonyms:
PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2
Type:
Protein
Mol. Mass.:
82806.72
Organism:
n/a
Description:
P31343
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
 
Inhibitor
Name:
BDBM474356
Synonyms:
(S)-6-((S)-(4-fluorophenyl)(m-tolyl)methyl)- 11-hydroxy-5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-10- one | US10858366, Example 38 | US11453677, Example 38
Type:
Small organic molecule
Emp. Form.:
C23H19FN4O2
Mol. Mass.:
402.421
SMILES:
Cc1cccc(c1)[C@@H]([C@H]1Cn2ccnc2-c2c(O)c(=O)cnn12)c1ccc(F)cc1 |r|
Structure:
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