Reaction Details Report a problem with these data
Target
Polymerase acidic protein
Ligand
BDBM474364
Substrate
n/a
Meas. Tech.
Endonuclease Inhibition Assay
IC50
40.0±n/a nM
Citation
 Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent  US11453677 Publication Date 9/27/2022 
Target
Name:
Polymerase acidic protein
Synonyms:
PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2
Type:
Protein
Mol. Mass.:
82806.72
Organism:
n/a
Description:
P31343
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
 
Inhibitor
Name:
BDBM474364
Synonyms:
(S)-6-benzhydryl-3-(difluoromethyl)-11- hydroxy-5,6-dihydro-10H-imidazo[1,2- a]pyrido[2,1-c]pyrazin-10-one | US10858366, Example 57 | US11453677, Example 57
Type:
Small organic molecule
Emp. Form.:
C24H19F2N3O2
Mol. Mass.:
419.4234
SMILES:
Oc1c2-c3ncc(C(F)F)n3C[C@H](C(c3ccccc3)c3ccccc3)n2ccc1=O |r|
Structure:
Search PDB for entries with ligand similarity: