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Target
Transcriptional enhancer factor TEF-1
Ligand
BDBM574517
Substrate
n/a
Meas. Tech.
TEAD Inhibition Assay
EC50
<100±n/a nM
Citation
 Castro, AC TEAD inhibitors and uses thereof US Patent  US11458149 Publication Date 10/4/2022 
Target
Name:
Transcriptional enhancer factor TEF-1
Synonyms:
NTEF-1 | Protein GT-IIC | TCF-13 | TCF13 | TEA domain family member 1 | TEAD-1 | TEAD1 | TEAD1_HUMAN | TEF1 | Transcription factor 13 | Transcriptional enhancer factor TEF-1
Type:
PROTEIN
Mol. Mass.:
47954.57
Organism:
Homo sapiens
Description:
ChEMBL_109666
Residue:
426
Sequence:
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
  
Inhibitor
Name:
BDBM574517
Synonyms:
US11458149, Compound I-70
Type:
Small organic molecule
Emp. Form.:
C16H18F3NO2
Mol. Mass.:
313.3148
SMILES:
FC(F)(F)c1ccc(O[C@H]2CCC(CC2)NC(=O)C=C)cc1 |r,wU:9.8,(8.05,1.67,;6.72,.9,;7.49,-.43,;5.95,2.23,;5.38,.13,;5.33,-1.44,;4,-2.21,;2.67,-1.44,;1.33,-2.21,;,-1.44,;-1.33,-2.21,;-2.67,-1.44,;-2.67,.1,;-1.33,.87,;,.1,;-4,.87,;-5.33,.1,;-5.33,-1.44,;-6.67,.87,;-8,.1,;2.67,.1,;4,.87,)|
Structure:
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