Reaction Details Report a problem with these data
Target
Transmembrane anterior posterior transformation protein 1 homolog
Ligand
BDBM575095
Substrate
n/a
Meas. Tech.
Assessing Antiviral Activity Against Human Cytomegalovirus (HCMV)
IC50
553±n/a nM
Citation
 Remiszewski, S; Chiang, LW; Murphy, EA; Sun, Q; Kayser, F; Fink, SJ Broad spectrum antiviral compositions and methods US Patent  US11459321 Publication Date 10/4/2022 
Target
Name:
Transmembrane anterior posterior transformation protein 1 homolog
Synonyms:
CMVFR | Cytomegalovirus partial fusion receptor | TAPT1 | TAPT1_HUMAN
Type:
Protein
Mol. Mass.:
64270.48
Organism:
Human
Description:
Q6NXT6
Residue:
567
Sequence:
MAGVGDAAAPGEGGGGGVDGPQRDGRGEAEQPGGSGGQGPPPAPQLTETLGFYESDRRRERRRGRTELSLLRFLSAELTRGYFLEHNEAKYTERRERVYTCLRIPRELEKLMVFGIFLCLDAFLYVFTLLPLRVFLALFRLLTLPCYGLRDRRLLQPAQVCDILKGVILVICYFMMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDALYWTATEPKERKRAHIGVIPHFFMAVLYVFLHAILIMVQATTLNVAFNSHNKSLLTIMMSNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWVLFPDVCMVIASEIAVDIVKHAFITKFNDITADVYSEYRASLAFDLVSSRQKNAYTDYSDSVARRMGFIPLPLAVLLIRVVTSSIKVQGILSYACVILFYFGLISLKVLNSIVLLGKSCQYVKEAKMEEKLSNPPATCTPGKPSSKSQNKCKPSQGLSTEENLSASITKQPIHQKENIIPLLVTSNSDQFLTTPDGDEKDITQDNSELKHRSSKKDLLEIDRFTICGNRID
  
Inhibitor
Name:
BDBM575095
Synonyms:
US11459321, Example 41
Type:
Small organic molecule
Emp. Form.:
C24H22N6O2S
Mol. Mass.:
458.535
SMILES:
O=C1OCCN1c1ccc2CCN(Cc2c1)c1ncc(Cc2ccc(nc2)-n2cccn2)s1
Structure:
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