Reaction Details Report a problem with these data
Target
Activin receptor type-1 [147-509]
Ligand
BDBM575137
Substrate
n/a
Meas. Tech.
ALK2 HTRF Assay
IC50
<1±n/a nM
Citation
 Pan, J; Roach, J; Mei, S; He, C; Wu, L; Yao, W Imidazopyridazine and imidazopyridine compounds and uses thereof US Patent  US11459329 Publication Date 10/4/2022 
Target
Name:
Activin receptor type-1 [147-509]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41331.39
Organism:
Homo sapiens (Human)
Description:
aa147-end
Residue:
363
Sequence:
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM575137
Synonyms:
US11459329, Example 11
Type:
Small organic molecule
Emp. Form.:
C33H31N7O
Mol. Mass.:
541.6455
SMILES:
Cc1nn2c(cnc2cc1-c1ccc(cc1)N1CCN(CCO)CC1)-c1ccnc2cc(ccc12)-c1ccncc1
Structure:
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