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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM458582
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
Ki
0.110±n/a nM
Citation
 Yoshinaga, H; Ikuma, Y; Ikeda, J; Adachi, S; Mitsunuma, H; Aihara, Y; Besnard, J; Bell, AS Substituted lactams showing serotonin 5-HT receptor activity US Patent  US11466007 Publication Date 10/11/2022 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM458582
Synonyms:
US10745401, Example 56 | US11466007, Example 56
Type:
Small organic molecule
Emp. Form.:
C20H24N6OS
Mol. Mass.:
396.509
SMILES:
Cn1cnc2CCN(CCN3CCN(CC3)c3nsc4ccccc34)C(=O)c12
Structure:
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