Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Ligand
BDBM384159
Substrate
n/a
Meas. Tech.
PTPN11 Enzymatic Assay
IC50
193±n/a nM
Citation
 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C Heterocyclic inhibitors of PTPN11 US Patent  US11466017 Publication Date 10/11/2022 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Synonyms:
PTN11_HUMAN | PTP2C | PTPN11 | Protein-tyrosine phosphatase 1D | SHPTP2 | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)(E76K)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68019.14
Organism:
Homo sapiens (Human)
Description:
Q06124[E76K]
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM384159
Synonyms:
(R)-8-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine | US10280171, Example 46 | US10851110, Example 46 | US11466017, Example 46
Type:
Small organic molecule
Emp. Form.:
C20H22Cl2N6
Mol. Mass.:
417.335
SMILES:
N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 |r|
Structure:
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