Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM576064
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
9.10±n/a nM
Citation
 Xu, Y; Xu, X; Wang, J; Ding, L Compound functioning as bromodomain protein inhibitor, and composition US Patent  US11466034 Publication Date 10/11/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM576064
Synonyms:
6-methyl-4-(2-methyl-1-(4- (trifluoromethyl)benzyl)-1H- imidazo[4,5-b]pyrazin-6-yl)-1H- pyrrolo[2,3-c]pyridin-7(6H)- one | US11466034, Example 19
Type:
Small organic molecule
Emp. Form.:
C22H17F3N6O
Mol. Mass.:
438.4052
SMILES:
Cc1nc2ncc(nc2n1Cc1ccc(cc1)C(F)(F)F)-c1cn(C)c(=O)c2[nH]ccc12
Structure:
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