Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM576085
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
7.30±n/a nM
Citation
 Xu, Y; Xu, X; Wang, J; Ding, L Compound functioning as bromodomain protein inhibitor, and composition US Patent  US11466034 Publication Date 10/11/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM576085
Synonyms:
Compound 38 (4-(1-(2,6-dichlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one) | US11466034, Example 38
Type:
Small organic molecule
Emp. Form.:
C30H24Cl2N4O3S
Mol. Mass.:
591.508
SMILES:
Cc1cc2ncc(cc2n1Cc1c(Cl)cccc1Cl)-c1cn(C)c(=O)c2n(ccc12)S(=O)(=O)c1ccc(C)cc1
Structure:
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