Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM576087
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
10.5±n/a nM
Citation
 Xu, Y; Xu, X; Wang, J; Ding, L Compound functioning as bromodomain protein inhibitor, and composition US Patent  US11466034 Publication Date 10/11/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM576087
Synonyms:
Compound 40 (4-(1-((4-chlorophenyl)sulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one) | US11466034, Example 40
Type:
Small organic molecule
Emp. Form.:
C28H21ClN4O5S2
Mol. Mass.:
593.073
SMILES:
Cc1ccc(cc1)S(=O)(=O)n1ccc2c(cn(C)c(=O)c12)-c1ccc2ccn(c2n1)S(=O)(=O)c1ccc(Cl)cc1
Structure:
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