Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM576106
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
1.60±n/a nM
Citation
 Xu, Y; Xu, X; Wang, J; Ding, L Compound functioning as bromodomain protein inhibitor, and composition US Patent  US11466034 Publication Date 10/11/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM576106
Synonyms:
N-(5-(6-methyl-7-oxo-6,7- dihydro-1H-pyrrolo[2,3-c]pyridin- 4-yl)-3-(4-(trifluoromethyl) benzyl)-3H-imidazo[4,5-b] pyridin-7-yl)ethanesulfonamide | US11466034, Example 58
Type:
Small organic molecule
Emp. Form.:
C24H21F3N6O3S
Mol. Mass.:
530.522
SMILES:
CCS(=O)(=O)Nc1cc(nc2n(Cc3ccc(cc3)C(F)(F)F)cnc12)-c1cn(C)c(=O)c2[nH]ccc12
Structure:
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