Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM576114
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
1.10±n/a nM
Citation
 Xu, Y; Xu, X; Wang, J; Ding, L Compound functioning as bromodomain protein inhibitor, and composition US Patent  US11466034 Publication Date 10/11/2022 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM576114
Synonyms:
N-(3-(2,4-difluorobenzyl)-2- methyl-5-(6-methyl-7-oxo-6,7- dihydro-1H-pyrrolo[2,3-c] pyridin-4-yl)-3H-imidazo[4,5- b]pyridin-7-yl)ethanesulfonamide | US11466034, Example 64
Type:
Small organic molecule
Emp. Form.:
C24H22F2N6O3S
Mol. Mass.:
512.532
SMILES:
CCS(=O)(=O)Nc1cc(nc2n(Cc3ccc(F)cc3F)c(C)nc12)-c1cn(C)c(=O)c2[nH]ccc12
Structure:
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