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Target
Protein cereblon
Ligand
BDBM576154
Substrate
n/a
Meas. Tech.
Protocol for Fluorescent Polarization assay
IC50
1588±n/a nM
Citation
 Alexander, F; Oliv, E; Bernhard, F; Mirco, M; Amine, S; Rajesh, C; Hannah, ZW; Jamieson, CJ; Ian, C; Thomas, R ISOINDOLINONE COMPOUNDS WIPO 0:0 (2021) [PubMed] 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM576154
Synonyms:
WO2021069705, Compound 24
Type:
Small organic molecule
Emp. Form.:
C22H22N4O4
Mol. Mass.:
406.4345
SMILES:
O=C(NCc1ccccc1)NCc1ccc2CN(C3CCC(=O)NC3=O)C(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: