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Target
Retina-specific copper amine oxidase
Ligand
BDBM576484
Substrate
n/a
Meas. Tech.
SSAO Activity Assay
IC50
<20±n/a nM
Citation
 Ren, Z; Sun, X; Xu, Q SSAO inhibitors and use thereof US Patent  US11472769 Publication Date 10/18/2022 
Target
Name:
Retina-specific copper amine oxidase
Synonyms:
AOC2 | AOC2_HUMAN | Retina-specific amine oxidase, copper containing
Type:
PROTEIN
Mol. Mass.:
83681.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_157252
Residue:
756
Sequence:
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF
  
Inhibitor
Name:
BDBM576484
Synonyms:
(1s,4s)-4-(((4-(((E)-2-(aminomethyl)- 3- fluoroallyl)oxy)phenyl)sulfonyl) methyl)cyclohexan-1-ol | US11472769, Compound 15
Type:
Small organic molecule
Emp. Form.:
C17H24FNO4S
Mol. Mass.:
357.44
SMILES:
NC\C(COc1ccc(cc1)S(=O)(=O)C[C@@H]1CC[C@H](O)CC1)=C/F |r,wU:15.15,18.19,(8.67,1.54,;7.34,.77,;6,1.54,;4.67,.77,;3.33,1.54,;2,.77,;2,-.77,;.67,-1.54,;-.67,-.77,;-.67,.77,;.67,1.54,;-2,-1.54,;-2.77,-2.87,;-1.23,-2.87,;-3.33,-.77,;-4.67,-1.54,;-6,-.77,;-7.34,-1.54,;-7.34,-3.08,;-8.67,-3.85,;-6,-3.85,;-4.67,-3.08,;6,3.08,;7.34,3.85,)|
Structure:
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