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Target
Isoform Tau-F of Microtubule-associated protein tau
Ligand
BDBM576627
Substrate
n/a
Meas. Tech.
CONFA Assay
IC50
1700±n/a nM
Citation
 Davidowitz, EJ; Moe, JG; Reitz, AB; Bian, H; Gluchowski, C; Hendrix, J; Yehaskel, AS; McDonnell, ME; Loughran, HM Quinazolinones that inhibit the formation of tau oligomers and their method of use US Patent  US11472776 Publication Date 10/18/2022 
Target
Name:
Isoform Tau-F of Microtubule-associated protein tau
Synonyms:
MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45857.42
Organism:
Homo sapiens (Human)
Description:
P10636-8
Residue:
441
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM576627
Synonyms:
US11472776, Example 16
Type:
Small organic molecule
Emp. Form.:
C22H19N3O3S
Mol. Mass.:
405.47
SMILES:
CCc1ccc(cc1O)-n1c(nc2ccsc2c1=O)-c1ccc(NC(C)=O)cc1
Structure:
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