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Target
Growth arrest-specific protein 6
Ligand
BDBM308138
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
183±n/a nM
Citation
 Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity US Patent  US9649309 Publication Date 5/16/2017 
Target
Name:
Growth arrest-specific protein 6
Synonyms:
AXL receptor tyrosine kinase ligand | AXLLG | GAS-6 | GAS6 | GAS6_HUMAN
Type:
PROTEIN
Mol. Mass.:
74914.43
Organism:
Homo sapiens (Human)
Description:
Q14393
Residue:
678
Sequence:
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
  
Inhibitor
Name:
BDBM308138
Synonyms:
US9649309, Compound UNC2886A
Type:
Small organic molecule
Emp. Form.:
C26H38N6O2
Mol. Mass.:
466.6189
SMILES:
CCCCNc1ncc(C(=O)NCc2ccc(cc2)N2CCCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(-10.52,-2.84,;-9.19,-2.07,;-7.85,-2.84,;-6.52,-2.07,;-5.19,-2.84,;-3.85,-2.07,;-2.52,-2.84,;-1.18,-2.07,;-1.18,-.53,;.15,.24,;.15,1.78,;1.48,-.53,;2.82,.24,;4.15,-.53,;4.15,-2.07,;5.48,-2.84,;6.82,-2.07,;6.82,-.53,;5.48,.24,;8.15,-2.84,;8.15,-4.38,;9.62,-4.86,;10.52,-3.61,;9.62,-2.37,;-2.52,.24,;-2.52,1.78,;-3.85,2.55,;-5.19,1.78,;-6.52,2.55,;-6.52,4.09,;-7.85,4.86,;-5.19,4.86,;-3.85,4.09,;-3.85,-.53,)|
Structure:
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