Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM577788
Substrate
n/a
Meas. Tech.
chemotaxis assay
IC50
<5±n/a nM
Citation
 Fan, P; Lange, CW; Malathong, V; Mali, VR; Punna, S; Tanaka, H; Zeng, Y; Zhang, P Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors US Patent  US11478460 Publication Date 10/25/2022 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM577788
Synonyms:
US11478460, Compound 1.128
Type:
Small organic molecule
Emp. Form.:
C27H25Cl2FN6O
Mol. Mass.:
539.431
SMILES:
Cc1cc(NC(N)=O)c(F)cc1-c1c2CN(CCc2nn1-c1c(C)cccc1C)c1ncc(Cl)cc1Cl |(-.13,.21,;.27,-1.28,;1.76,-1.68,;2.16,-3.17,;3.64,-3.57,;4.73,-2.48,;6.22,-2.87,;4.33,-.99,;1.07,-4.26,;1.47,-5.74,;-.42,-3.86,;-.82,-2.37,;-2.31,-1.97,;-2.78,-.51,;-2.01,.83,;-2.78,2.16,;-4.32,2.16,;-5.09,.83,;-4.32,-.51,;-4.8,-1.97,;-3.55,-2.88,;-3.55,-4.42,;-4.89,-5.19,;-6.22,-4.42,;-4.89,-6.73,;-3.55,-7.5,;-2.22,-6.73,;-2.22,-5.19,;-.89,-4.42,;-2.01,3.49,;-.47,3.49,;.3,4.83,;-.47,6.16,;.3,7.5,;-2.01,6.16,;-2.78,4.83,;-4.32,4.83,)|
Structure:
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