Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM579314
Substrate
n/a
Meas. Tech.
IP Accumulation Assay
EC50
0.000±n/a nM
Citation
 Brabander, JD; Rosenbaum, D; Liang, Q; Wang, W OX2R compounds US Patent  US11479560 Publication Date 10/25/2022 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM579314
Synonyms:
US11479560, Title ww6-157
Type:
Small organic molecule
Emp. Form.:
C27H31N3O
Mol. Mass.:
413.5545
SMILES:
C[C@@H](O)C(Cc1ccc(C)cc1)n1c2ccccc2n(C(C)c2ccc(C)cc2)c1=N |r|
Structure:
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