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Target
Ubiquitin carboxyl-terminal hydrolase 1
Ligand
BDBM580032
Substrate
n/a
Meas. Tech.
Inhibitor Assay
IC50
55±n/a nM
Citation
 Brenneman, JB; Krall, EB; Schlabach, M; Wylie, AA Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors US Patent  US11485736 Publication Date 11/1/2022 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 1
Synonyms:
Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48  | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP
Type:
PROTEIN
Mol. Mass.:
88191.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104169
Residue:
785
Sequence:
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNKKNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSDQTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
  
Inhibitor
Name:
BDBM580032
Synonyms:
US11485736, Compound Table 3.16
Type:
Small organic molecule
Emp. Form.:
C25H20F4N8O
Mol. Mass.:
524.4729
SMILES:
COc1ncnc(C2CC2)c1-c1ncc2cnn(Cc3ccc(-c4nc(cn4C)C(F)(F)F)c(F)c3)c2n1
Structure:
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