Reaction Details
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Report a problem with these dataTarget
Histone acetyltransferase KAT5
Ligand
BDBM580678
Substrate
n/a
Meas. Tech.
Kat5 Assay
Ki
130±n/a nM
Citation
Bozikis, YE; Camerino, MA; Kung, P; Stupple, PA; Sutton, SC Benzisoxazole sulfonamide derivatives US Patent US11492346 Publication Date 11/8/2022 More Info.:
Target
Name:
Histone acetyltransferase KAT5
Synonyms:
HTATIP | KAT5 | KAT5_HUMAN | TIP60
Type:
PROTEIN
Mol. Mass.:
58595.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796787
Residue:
513
Sequence:
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
Inhibitor
Name:
BDBM580678
Synonyms:
US11492346, Example 18
Type:
Small organic molecule
Emp. Form.:
C22H24N4O5S
Mol. Mass.:
456.515
SMILES:
COc1ccc(cc1S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12)C(C)C
Structure:
