Reaction Details
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Report a problem with these dataTarget
Histone acetyltransferase KAT5
Ligand
BDBM580733
Substrate
n/a
Meas. Tech.
Kat5 Assay
Ki
710±n/a nM
Citation
Bozikis, YE; Camerino, MA; Kung, P; Stupple, PA; Sutton, SC Benzisoxazole sulfonamide derivatives US Patent US11492346 Publication Date 11/8/2022 More Info.:
Target
Name:
Histone acetyltransferase KAT5
Synonyms:
HTATIP | KAT5 | KAT5_HUMAN | TIP60
Type:
PROTEIN
Mol. Mass.:
58595.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796787
Residue:
513
Sequence:
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
Inhibitor
Name:
BDBM580733
Synonyms:
US11492346, Example 73
Type:
Small organic molecule
Emp. Form.:
C22H19N5O4S
Mol. Mass.:
449.482
SMILES:
COc1cc(Cn2cccn2)cc2onc(NS(=O)(=O)c3c(C)ccc4cccnc34)c12
Structure:
