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Target
Histone acetyltransferase KAT5
Ligand
BDBM580669
Substrate
n/a
Meas. Tech.
Kat5 Assay
Ki
570±n/a nM
Citation
 Bozikis, YE; Camerino, MA; Kung, P; Stupple, PA; Sutton, SC Benzisoxazole sulfonamide derivatives US Patent  US11492346 Publication Date 11/8/2022 
Target
Name:
Histone acetyltransferase KAT5
Synonyms:
HTATIP | KAT5 | KAT5_HUMAN | TIP60
Type:
PROTEIN
Mol. Mass.:
58595.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796787
Residue:
513
Sequence:
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
  
Inhibitor
Name:
BDBM580669
Synonyms:
US11492346, Example 9 | US11492346, Example 90 | US11492346, Example 91 | US11492346, Example 98
Type:
Small organic molecule
Emp. Form.:
C20H20N4O6S
Mol. Mass.:
444.461
SMILES:
COc1cccc(OC)c1S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12
Structure:
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