Reaction Details Report a problem with these data
Target
RAC-alpha serine/threonine-protein kinase [1-472,474-480]
Ligand
BDBM580910
Substrate
n/a
Meas. Tech.
pAKT Protocol
IC50
480±n/a nM
Citation
 Stocking, EM; Wrasidlo, WJ Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways US Patent  US11492348 Publication Date 11/8/2022 
Target
Name:
RAC-alpha serine/threonine-protein kinase [1-472,474-480]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | pAKT
Type:
Enzyme
Mol. Mass.:
55594.17
Organism:
Homo sapiens (Human)
Description:
P31749[1-472,474-480]
Residue:
479
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFYSASGTA
  
Inhibitor
Name:
BDBM580910
Synonyms:
(2-(2-aminopyrimidin-5-yl)-6- morpholinopyridin-4-yl)(phenyl)methanone | US11492348, Compound 122
Type:
Small organic molecule
Emp. Form.:
C20H19N5O2
Mol. Mass.:
361.3972
SMILES:
Nc1ncc(cn1)-c1cc(cc(n1)N1CCOCC1)C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: