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Target
Stimulator of interferon genes protein
Ligand
BDBM581008
Substrate
n/a
Meas. Tech.
STING SPR Binding Assay
Kd
120±n/a nM
Citation
 Emanuel, S; Richter, M; Connolly, PJ; Edwards, JP; Wang, G; Thatikonda, SK; Beigelman, L; Zhong, M; Bignan, G; Schepens, W; Viellevoye, M; Thuring, JW Cyclic dinucleotides as sting agonists US Patent  US11492367 Publication Date 11/8/2022 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM581008
Synonyms:
US11492367, Compound 2
Type:
Small organic molecule
Emp. Form.:
C21H26N10O13P2
Mol. Mass.:
688.4379
SMILES:
CNc1ncnc2c(cnn12)C1OC2COP(O)(=O)OC3C(O)C(COP(O)(=O)OC2C1O)OC3n1cnc2c1nc(N)[nH]c2=O
Structure:
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