Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM581657
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
0.300±n/a nM
Citation
 Alcazar, J; Ameriks, MK; Berry, CB; Garcia-Reynaga, P; Samant, AV; Vega-Ramiro, JA Azaspirocycles as monoacylglycerol lipase modulators US Patent  US11505546 Publication Date 11/22/2022 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM581657
Synonyms:
(2s,4s)-2-(6-(3-Cyclopropylphenyl)-2-azaspiro[3.3]heptane-2-carbonyl)-7-oxa-5- azaspiro[3.4]octan-6-one | US11505546, Example 72
Type:
Small organic molecule
Emp. Form.:
C22H26N2O3
Mol. Mass.:
366.4534
SMILES:
O=C([C@H]1C[C@@]2(C1)COC(=O)N2)N1CC2(CC(C2)c2cccc(c2)C2CC2)C1 |r,wU:2.1,wD:4.4,(-2.45,3.78,;-2.45,2.24,;-3.78,1.47,;-4.18,-.01,;-5.67,.39,;-5.27,1.87,;-5.59,-1.15,;-7.02,-1.7,;-7.99,-.51,;-9.53,-.51,;-7.15,.78,;-1.11,1.47,;-.71,-.01,;.77,.38,;1.17,-1.1,;2.66,-.7,;2.26,.78,;3.99,-1.47,;3.99,-3.01,;5.33,-3.78,;6.66,-3.01,;6.66,-1.47,;5.33,-.7,;7.99,-.7,;9.53,-.7,;8.76,.63,;.37,1.87,)|
Structure:
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