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Target
Protein cereblon
Ligand
BDBM585774
Substrate
n/a
Meas. Tech.
TBD
Ki
8500±n/a nM
Citation
 Gray, N; Zhang, T; Fischer, E; He, Z; Du, G; Donovan, K; Nowak, R; Yuan, JT Ligands to cereblon (CRBN) US Patent  US11530219 Publication Date 12/20/2022 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM585774
Synonyms:
US11530219, Compound 1
Type:
Small organic molecule
Emp. Form.:
C25H22FN7O4
Mol. Mass.:
503.4851
SMILES:
Fc1ccccc1Nc1nccc(NCC(=O)Nc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)n1
Structure:
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