Reaction Details Report a problem with these data
Target
Leukotriene C4 synthase
Ligand
BDBM223239
Substrate
n/a
Meas. Tech.
In Vitro hLTC4 Synthase Enzyme Assay
IC50
22.0±n/a nM
Citation
Ronn, R; Lindh, CJ; Ringberg, E; Andersson, HB; Nilsson, P; Schaal, WR; Munck af Rosenschöld, M; Nikitidis, A; Nikitidis, G; Johannesson, P; Tyrchan, C Compounds and uses US Patent US9657001 Publication Date 5/23/2017
More Info.:
Target
Name:
Leukotriene C4 synthase
Synonyms:
LTC4 synthase | LTC4S | LTC4S_HUMAN | Leukotriene-C(4) synthase
Type:
PROTEIN
Mol. Mass.:
16575.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_961179
Residue:
150
Sequence:
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA
Inhibitor
Name:
BDBM223239
Synonyms:
2-(5-((Cyclopropylmethyl)(4-methylbenzyl)amino)-3-methoxypicolinoyl)cyclopropanecarboxylic acid | US20160326143, 14 | US9657001, 14
Type:
Small Organic Molecule
Emp. Form.:
C23H26N2O4
Mol. Mass.:
394.4635
SMILES:
COc1cc(cnc1C(=O)C1CC1C(O)=O)N(CC1CC1)Cc1ccc(C)cc1