Reaction Details Report a problem with these data
Target
Leukotriene C4 synthase
Ligand
BDBM223261
Substrate
n/a
Meas. Tech.
In Vitro hLTC4 Synthase Enzyme Assay
IC50
9.00±n/a nM
Citation
 Ronn, R; Lindh, CJ; Ringberg, E; Andersson, HB; Nilsson, P; Schaal, WR; Munck af Rosenschöld, M; Nikitidis, A; Nikitidis, G; Johannesson, P; Tyrchan, C Compounds and uses US Patent  US9657001 Publication Date 5/23/2017 
Target
Name:
Leukotriene C4 synthase
Synonyms:
LTC4 synthase | LTC4S | LTC4S_HUMAN | Leukotriene-C(4) synthase
Type:
PROTEIN
Mol. Mass.:
16575.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_961179
Residue:
150
Sequence:
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA
  
Inhibitor
Name:
BDBM223261
Synonyms:
2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen-5-yl)amino)-3-methoxypicolinoyl)cyclopropanecarboxylic acid | US20160326143, 36 | US9657001, 36
Type:
Small Organic Molecule
Emp. Form.:
C27H26N2O4
Mol. Mass.:
442.5063
SMILES:
COc1cc(cnc1C(=O)C1CC1C(O)=O)N(CC1CC1)c1ccc2CCc3cccc1c23
Structure:
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