Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50507687
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
1191±n/a nM
Citation
 Chern, J; Yu, C; Liu, J; Ho, Y; Wu, C; Huang, C; Hung, P Histone deacetylases (HDACs) inhibitors US Patent  US11535598 Publication Date 12/27/2022 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50507687
Synonyms:
CHEMBL4457073 | US11535598, Compound 25
Type:
Small organic molecule
Emp. Form.:
C22H19N3O4S
Mol. Mass.:
421.469
SMILES:
ONC(=O)c1cc(Cn2c3ccccc3c(=O)n(CCc3ccccc3)c2=O)cs1
Structure:
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