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Target
Tyrosine-protein kinase Mer [557-882,H628Q,R794A]
Ligand
BDBM588253
Substrate
n/a
Meas. Tech.
Mer Kinase Assay
IC50
<10±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Tso, K; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11542259 Publication Date 1/3/2023 
Target
Name:
Tyrosine-protein kinase Mer [557-882,H628Q,R794A]
Synonyms:
MER | MERTK | MERTK_HUMAN | Tyrosine-protein kinase Mer (557-882)(H628Q)(R794A)
Type:
n/a
Mol. Mass.:
37500.46
Organism:
Tyrosine-protein kinase Mer
Description:
Q12866[557-882,H628Q,R794A]
Residue:
326
Sequence:
RRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSE
  
Inhibitor
Name:
BDBM588253
Synonyms:
1-N'-(4-fluorophenyl)-1-N-[4- [7-(methylcarbamoyl)quinolin- 4-yl]oxyphenyl]cyclopropane- 1,1-dicarboxamide | US11542259, Compound 165
Type:
Small organic molecule
Emp. Form.:
C28H23FN4O4
Mol. Mass.:
498.505
SMILES:
CNC(=O)c1ccc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)ccnc2c1
Structure:
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