Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor MET Isoform 2 [974-1390,A1209G,V1290L]
Ligand
BDBM588258
Substrate
n/a
Meas. Tech.
Met Kinase Assay
IC50
<10±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Tso, K; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11542259 Publication Date 1/3/2023 
Target
Name:
Hepatocyte growth factor receptor MET Isoform 2 [974-1390,A1209G,V1290L]
Synonyms:
Hepatocyte growth factor receptor MET (974-1390)(A1209G)(V1290L) | MET | MET_HUMAN
Type:
n/a
Mol. Mass.:
47001.54
Organism:
Homo sapiens (Human)
Description:
P08581-2[974-1390,A1209G,V1290L]
Residue:
417
Sequence:
KKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKAMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSE
  
Inhibitor
Name:
BDBM588258
Synonyms:
1-N'-(4-fluorophenyl)-1-N- [4-[7-methoxy-6- (1-methylpyrazol-4- yl)quinolin-4- yl]oxyphenyl]cyclopropane- 1,1-dicarboxamide | US11542259, Compound 182
Type:
Small organic molecule
Emp. Form.:
C31H26FN5O4
Mol. Mass.:
551.5676
SMILES:
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1-c1cnn(C)c1
Structure:
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