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Target
Tyrosine-protein kinase Mer [557-882,H628Q,R794A]
Ligand
BDBM588265
Substrate
n/a
Meas. Tech.
Mer Kinase Assay
IC50
<10±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Tso, K; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11542259 Publication Date 1/3/2023 
Target
Name:
Tyrosine-protein kinase Mer [557-882,H628Q,R794A]
Synonyms:
MER | MERTK | MERTK_HUMAN | Tyrosine-protein kinase Mer (557-882)(H628Q)(R794A)
Type:
n/a
Mol. Mass.:
37500.46
Organism:
Tyrosine-protein kinase Mer
Description:
Q12866[557-882,H628Q,R794A]
Residue:
326
Sequence:
RRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSE
  
Inhibitor
Name:
BDBM588265
Synonyms:
US11542259, Compound 195 | tert-butyl 3-[4-[4-[[1-[(4- fluorophenyl)carbamoyl]- cyclopropanecarbonyl]- amino]phenoxy]-7- methoxyquinolin-6-yl]-3- hydroxyazetidine-1- carboxylate
Type:
Small organic molecule
Emp. Form.:
C35H35FN4O7
Mol. Mass.:
642.6734
SMILES:
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1C1(O)CN(C1)C(=O)OC(C)(C)C
Structure:
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