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Target
Proteasome subunit alpha type-6
Ligand
BDBM588478
Substrate
n/a
Meas. Tech.
Proteasome Inhibitory Activity
IC50
4.86±n/a nM
Citation
 Qin, Y Synthesis of peptide borate ester compound and use thereof US Patent  US11542283 Publication Date 1/3/2023 
Target
Name:
Proteasome subunit alpha type-6
Synonyms:
27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K
Type:
PROTEIN
Mol. Mass.:
27399.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
246
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
  
Inhibitor
Name:
BDBM588478
Synonyms:
(R)-N-(2,5-dichlorobenzoyl)-3- methylmercaptopropionamido-D-leucine boric acid | US11542283, Compound IV-9
Type:
Small organic molecule
Emp. Form.:
C16H23BCl2N2O4S
Mol. Mass.:
421.147
SMILES:
CSC[C@H](NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(C)C)B(O)O |r|
Structure:
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