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Target
Proteasome subunit alpha type-6
Ligand
BDBM588480
Substrate
n/a
Meas. Tech.
Proteasome Inhibitory Activity
IC50
8.20±n/a nM
Citation
 Qin, Y Synthesis of peptide borate ester compound and use thereof US Patent  US11542283 Publication Date 1/3/2023 
Target
Name:
Proteasome subunit alpha type-6
Synonyms:
27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K
Type:
PROTEIN
Mol. Mass.:
27399.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
246
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
  
Inhibitor
Name:
BDBM588480
Synonyms:
(S)-N-(2,5-dichlorobenzoyl)-3- methoxypropionamido-D-leucine borate citrate | US11542283, Compound V-8B
Type:
Small organic molecule
Emp. Form.:
C22H27BCl2N2O10
Mol. Mass.:
561.174
SMILES:
COC[C@H](NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(C)C)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O |r|
Structure:
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