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Target
Proteasome subunit alpha type-6
Ligand
BDBM50462621
Substrate
n/a
Meas. Tech.
Proteasome Inhibitory Activity
IC50
7.47±n/a nM
Citation
 Qin, Y Synthesis of peptide borate ester compound and use thereof US Patent  US11542283 Publication Date 1/3/2023 
Target
Name:
Proteasome subunit alpha type-6
Synonyms:
27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K
Type:
PROTEIN
Mol. Mass.:
27399.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
246
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
  
Inhibitor
Name:
BDBM50462621
Synonyms:
CHEMBL1813256 | MLN-9708 | US11542283, Compound MLN-9708
Type:
Small organic molecule
Emp. Form.:
C20H23BCl2N2O9
Mol. Mass.:
517.122
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O |r|
Structure:
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