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Target
Stimulator of interferon genes protein
Ligand
BDBM588524
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
<1000±n/a nM
Citation
 Vyskocil, S; Ciavarri, J; Cullis, C; England, DB; Gould, AE; Greenspan, P; Hu, Y; Langston, S; Li, G; Mizutani, H; Okaniwa, M Sting modulator compounds, and methods of making and using US Patent  US11542293 Publication Date 1/3/2023 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM588524
Synonyms:
2-amino-9-[(2S,5R,7R,8R,10S,12aR,14R,15aS,16R)-16-hydroxy-2,10-dioxido-14- (pyrimidin-4-ylamino)-2,10-disulfanyldecahydro-5,8-methanocyclopenta[1][1,3,6, 9,11,2,10]pentaoxadiphosphacyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one | US11542293, Compound I-2a | US11542293, Compound I-2b
Type:
Small organic molecule
Emp. Form.:
C20H26N8O9P2S2
Mol. Mass.:
648.546
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=O)O[C@H]3C[C@@H](C[C@@H]3COP(S)(=O)O[C@@H]1[C@@H]2O)Nc1ccncn1 |r|
Structure:
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