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Target
Stimulator of interferon genes protein
Ligand
BDBM588599
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
<1000±n/a nM
Citation
 Vyskocil, S; Ciavarri, J; Cullis, C; England, DB; Gould, AE; Greenspan, P; Hu, Y; Langston, S; Li, G; Mizutani, H; Okaniwa, M Sting modulator compounds, and methods of making and using US Patent  US11542293 Publication Date 1/3/2023 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM588599
Synonyms:
US11542293, Compound I-46
Type:
Small organic molecule
Emp. Form.:
C20H25FN8O11P2
Mol. Mass.:
634.4054
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)O[C@@H]3[C@H](C[C@@H](Nc4ccncn4)[C@@H]3F)COP(O)(=O)O[C@@H]1[C@@H]2O |r|
Structure:
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