Reaction Details Report a problem with these data
Target
BDBP50000595
Ligand
BDBM139370
Substrate
n/a
Meas. Tech.
competitive radioligand displacement and functional assays
Ki
2.75±n/a nM
Citation
 Raymond, B SEROTONIN 5-HT2A, 5-HT2B, AND 5-HT2C RECEPTOR INVERSE AGONISTS WIPO 0:0 (2023) [PubMed] 
Target
Name:
Neutrophil cytosol factor 1
Synonyms:
47 kDa autosomal chronic granulomatous disease protein | 47 kDa neutrophil oxidase factor | NCF-1 | NCF-47K | NCF1 | NCF1_HUMAN | NOXO2 | Neutrophil NADPH oxidase factor 1 | Neutrophil cytosol factor 1 | Nox organizer 2 | Nox-organizing protein 2 | SH3 and PX domain-containing protein 1A | SH3PXD1A | p47-phox
Type:
PROTEIN
Mol. Mass.:
44694.41
Organism:
Homo sapiens
Description:
ChEMBL_103757
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM139370
Synonyms:
ACP-103 | Nuplazid | Pimavanserin | Pimavanserin hydrochloride | Pimavanserin tartrate | US20230348421, Compound Pimavanserin | WO2023288027, Cmpd PIMA | bis(1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)-3-(4-(2-methylpropoxy)benzyl)urea) (2R,3R)-2,3-dihydroxybutanedioate
Type:
Small organic molecule
Emp. Form.:
C25H34FN3O2
Mol. Mass.:
427.5548
SMILES:
CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1
Structure:
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