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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM581348
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Binding Assay
Ki
300±n/a nM
Citation
 Srinivasan, R; Hung, W Therapeutic compounds and methods of use thereof US Patent  US11548866 Publication Date 1/10/2023 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM581348
Synonyms:
US11504381, Compound 31 | US11548866, Compound 31
Type:
Small organic molecule
Emp. Form.:
C24H28Cl2N4O3
Mol. Mass.:
491.41
SMILES:
Nc1cc(Cl)cnc1N1[C@@H](CC2CCCC2)CN(C[C@H]1c1ccc(Cl)cc1)C(=O)CC(O)=O |r|
Structure:
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