Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM474838
Substrate
n/a
Meas. Tech.
Factor D Esterolytic Assay
IC50
>10000±n/a nM
Citation
 Kotian, PL; Babu, YS; Zhang, W; Vogeti, L; Wu, M; Chintareddy, VR; Raman, K Indole compounds and analogues thereof US Patent  US11559515 Publication Date 1/24/2023 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM474838
Synonyms:
US10849883, Compound 188a | US11559515, Compound 188a
Type:
Small organic molecule
Emp. Form.:
C26H26BrN7O3
Mol. Mass.:
564.434
SMILES:
CC(C)N(CC(=O)Nc1cccc(Br)n1)C(=O)Cn1nc(C(C)=O)c2cc(Nc3cccnc3)ccc12
Structure:
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