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Target
Large envelope protein
Ligand
BDBM590025
Substrate
n/a
Meas. Tech.
Assay Measuring Activity of Test Compounds on Viral Production from HepAD38 Cells
EC50
<100±n/a nM
Citation
 Haydar, SN; Li, L; Bures, MG; Rai, R; Bannen, L; Walker, M 5-membered heteroaryl carboxamide compounds for treatment of HBV US Patent  US11560370 Publication Date 1/24/2023 
Target
Name:
Large envelope protein
Synonyms:
HBSAG_HBVD3 | S
Type:
n/a
Mol. Mass.:
42772.52
Organism:
Hepatitis B virus
Description:
P03138
Residue:
389
Sequence:
MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWDFNPNKDTWPDANKVGAGAFGLGFTPPHGGLLGWSPQAQGILQTLPANPPPASTNRQSGRQPTPLSPPLRNTHPQAMQWNSTTFHQTLQDPRVRGLYFPAGGSSSGTVNPVLTTASPLSSIFSRIGDPALNMENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI
  
Inhibitor
Name:
BDBM590025
Synonyms:
US11560370, Compound AIA-276D
Type:
Small organic molecule
Emp. Form.:
C23H24ClFN4O2
Mol. Mass.:
442.914
SMILES:
COc1cccc(c1)[C@@H]1CC[C@@H](C1)c1nn(C)c(N)c1C(=O)Nc1ccc(F)c(Cl)c1 |r|
Structure:
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