Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM479516
Substrate
n/a
Meas. Tech.
Binding Affinities to Different Adenosine Receptors
IC50
2.60±n/a nM
Citation
 Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent  US11571420 Publication Date 2/7/2023 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM479516
Synonyms:
3-amino-6-(1H-benzo[d]imidazol-5-yl)- N-((3-fluoropyridin-2-yl)methyl)-5- (oxazol-2-yl)pyrazine-2-carboxamide | US10898481, Compound 47 | US11571420, Compound 47
Type:
Small organic molecule
Emp. Form.:
C21H15FN8O2
Mol. Mass.:
430.3946
SMILES:
Nc1nc(-c2ncco2)c(nc1C(=O)NCc1ncccc1F)-c1ccc2[nH]cnc2c1
Structure:
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