Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM479541
Substrate
n/a
Meas. Tech.
Binding Affinities to Different Adenosine Receptors
IC50
9.10±n/a nM
Citation
 Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent  US11571420 Publication Date 2/7/2023 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM479541
Synonyms:
3-amino-N-cyclobutyl-6-(3- methylimidazo[1,2-a]pyridin-6-yl)-5- (oxazol-2- yl)pyrazine-2-carboxamide | US10898481, Compound 218 | US11571420, Compound 218
Type:
Small organic molecule
Emp. Form.:
C20H19N7O2
Mol. Mass.:
389.4106
SMILES:
Cc1cnc2ccc(cn12)-c1nc(C(=O)NC2CCC2)c(N)nc1-c1ncco1
Structure:
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