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Target
Beclin 1/Bcl-2
Ligand
BDBM595547
Substrate
n/a
Meas. Tech.
High-Throughput Assay
IC50
<156±n/a nM
Citation
 Brabander, JD; Liang, Q; Levine, B; Chiang, W Small molecule inducers of autophagy US Patent  US11591319 Publication Date 2/28/2023 
Target
Name:
Beclin 1/Bcl-2
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Beclin-1
Synonyms:
BECN1 | BECN1_HUMAN | Beclin-1-C 35 kDa | Beclin-1-C 37 kDa | Coiled-coil myosin-like BCL2-interacting protein | GT197 | Protein GT197
Type:
PROTEIN
Mol. Mass.:
51874.54
Organism:
Homo sapiens
Description:
ChEMBL_118255
Residue:
450
Sequence:
MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
  
Component 2
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM595547
Synonyms:
US11591319, ID lqr-9-156
Type:
Small organic molecule
Emp. Form.:
C26H22BrN3O3
Mol. Mass.:
504.375
SMILES:
Brc1ccc(cc1)C(=O)N1N=C(CC1c1ccccc1)c1ccc(NC(=O)OCC=C)cc1 |c:11|
Structure:
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