Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM310228
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
470±n/a nM
Citation
 Chen, X; Cheng, AC; Connors, RV; Debenedetto, MV; Dransfield, PJ; Fu, Z; Harvey, JS; Heath, JA; Houze, J; Judd, TC; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor US Patent  US10150760 Publication Date 12/11/2018 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM310228
Synonyms:
US10150760, Example 15.0 | US10150760, Example 16.0 | US10150760, Example 17.0
Type:
Small organic molecule
Emp. Form.:
C22H27FN6O5S
Mol. Mass.:
506.55
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1 |r,wU:16.17,(-7.03,5.8,;-5.69,5.03,;-4.36,5.8,;-4.36,7.34,;-3.02,8.11,;-1.69,7.34,;-1.69,5.8,;-.36,5.03,;.98,5.8,;-3.02,5.03,;-3.02,3.49,;-1.78,2.59,;-.45,3.36,;.89,2.59,;2.22,1.82,;-.45,1.82,;2.22,3.36,;2.22,4.9,;3.56,2.59,;4.89,3.36,;6.22,2.59,;7.56,3.36,;7.56,4.9,;8.89,5.67,;6.22,5.67,;4.89,4.9,;-2.25,1.13,;-3.79,1.13,;-4.27,2.59,;-5.81,2.59,;-6.58,3.92,;-8.12,3.92,;-8.89,2.59,;-8.12,1.26,;-6.58,1.26,)|
Structure:
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