Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM474224
Substrate
n/a
Meas. Tech.
Binding Affinities to Different Adenosine Receptors
IC50
1067±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US11629147 Publication Date 4/18/2023 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM474224
Synonyms:
5-(5-amino-2-[[3-(difluoromethoxy)pyridin-2-yl] methyl]-7-(4-fluorophenyl)-[l, 2,4]Jtriazolo[l,5-c] pyrimidin-8-yl)-1-methyl-1,2-dihydropyridin-2-one | US10858365, Compound 20 | US11629147, Cmpd. 20
Type:
Small organic molecule
Emp. Form.:
C24H18F3N7O2
Mol. Mass.:
493.4406
SMILES:
Cn1cc(ccc1=O)-c1c(nc(N)n2nc(Cc3ncccc3OC(F)F)nc12)-c1ccc(F)cc1
Structure:
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