Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM474231
Substrate
n/a
Meas. Tech.
Binding Affinities to Different Adenosine Receptors
IC50
4.00±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US11629147 Publication Date 4/18/2023 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM474231
Synonyms:
6-[[5-amino-7-(4-fluorophenyl)-8-[imidazo[1,2-a] pyridin-6-yl]-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl] methyl]pyridin-2-amine | US10858365, Compound 37 | US11629147, Cmpd. 37
Type:
Small organic molecule
Emp. Form.:
C24H18FN9
Mol. Mass.:
451.4584
SMILES:
Nc1cccc(Cc2nc3c(-c4ccc5nccn5c4)c(nc(N)n3n2)-c2ccc(F)cc2)n1
Structure:
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