Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM474237
Substrate
n/a
Meas. Tech.
Binding Affinities to Different Adenosine Receptors
IC50
4.10±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US11629147 Publication Date 4/18/2023 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM474237
Synonyms:
5-(5-amino-7-(3-chlorophenyl)-2-((3-fluoropyrid in-2-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-8- yl)-l-methylpyridin-2(lH)-one | US10858365, Compound 70 | US11629147, Cmpd. 70
Type:
Small organic molecule
Emp. Form.:
C23H17ClFN7O
Mol. Mass.:
461.879
SMILES:
Cn1cc(ccc1=O)-c1c(nc(N)n2nc(Cc3ncccc3F)nc12)-c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: