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Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM600981
Substrate
n/a
Meas. Tech.
Biochemical Notum Enzymatic Activity Assay
IC50
3.60±n/a nM
Citation
 Fish, PV; Mahy, W; Willis, NJ; Woodward, H; Atkinson, BN; Bayle, ED; Sipthorp, J; Jones, EY; Zhao, Y; Vecchia, L; Ruza, RR Compounds which are inhibitors of Notum US Patent  US11634391 Publication Date 4/25/2023 
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM
Type:
PROTEIN
Mol. Mass.:
55706.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116492
Residue:
496
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
  
Inhibitor
Name:
BDBM600981
Synonyms:
2-(2,4-dichloro-3-(trifluoromethyl)phenyl)-5-(methoxy-d3)-1,3,4-oxadiazole | US11634391, Compound 241 | US11634391, Compound 243
Type:
Small organic molecule
Emp. Form.:
C10H5Cl2F3N2O2
Mol. Mass.:
313.06
SMILES:
COc1nnc(o1)-c1ccc(Cl)c(c1Cl)C(F)(F)F
Structure:
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