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Target
Nucleoprotein
Ligand
BDBM601540
Substrate
n/a
Meas. Tech.
Plaque Reduction Assay
EC50
28.0±n/a nM
Citation
 Cockerill, GS; Good, J; Cochrane, EJ Pharmaceutical compounds US Patent  US11634425 Publication Date 4/25/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM601540
Synonyms:
N-[(3S)-9-Fluoro- 2-oxo-5-phenyl- 1,3-dihydro-1,4- benzodiazepin-3- yl]-2-[6-(propan- 2-ylamino)pyridin- 3-yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide | US11634425, Example 74
Type:
Small organic molecule
Emp. Form.:
C30H25FN8O2
Mol. Mass.:
548.5703
SMILES:
CC(C)Nc1ccc(cn1)-c1nn2cccnc2c1C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O |t:26|
Structure:
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